Inhibition by early treatment with bromocriptine of spontaneous mammary tumour development in rats with no side-effects

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Abstract
: Temporary inhibition by CB-154 (bromocriptine) of pituitary prolactin secretion, which induced a decline in mammary gland DNA synthesis for 4–11 weeks of age, resulted in a marked suppression of spontaneous mammary tumour development in rats after one year of age. The treatment had no effect on reproduction and subsequent lactation immediately after the CB-154 injection or growth and function of the mammary glands and pituitary prolactin secretion in later life.