Release of furosemide from sustained release microcapsules prepared by phase separation technique

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Abstract
Furosemide Eudragit RL-100 sustained release microcapsules were prepared using phase separation technique. The results of the release studies, in sorensen phosphate buffer at PH 7.4, indicated good sustained release of the prepared microcapsules. Increasing drug to polymer ratio resulted in a decrease in the release, while increased release obtained by increasing the PH of the dissolution medium. Dosing of healthy human volunteers with sustained release microcapsules resulted in a reduced and sustained urine volume compared to the profuse diuresis obtained with the conventional furosemide capsules.