The biochemistry of organotin compounds. Trialkyltins and oxidative phosphorylation

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Abstract
Rat-liver mitochondria whose rate of oxidation of pyruvate may be increased three-to four-fold by the addition of potato apyrase, hexokinase and glucose and 2, 4-dinitrophenol have been used to examine the biochemistry of trlalkyltins. Oxidation induced by apyrase, 2, 4-dinitrophenol or hexoMnase and glucose, oxidation in the presence of excess of hexokinase and glucose and adenosine triphosphatase stimulated by 2, 4-dinitrophenol are all equally sensitive to inhibition by a trialkyltin. Seven trialkyltlns have been tested against these processes. The lower molecular-weight trialkyltins induce some adenosine triphosphatase activity in mitochondria and this has been correlated with a stimulation of the oxidation of pyruvate. It is concluded that trialkyltins inhibit a step in the energy-transferring chain between electron transport and the formation of adenosine triphosphate.