Potency of 3,3′,4,4′,5‐pentachlorobiphenyl (PCB 126), alone and in combination with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), to produce lake trout early life‐stage mortality

1 December 1995

journal article
research article
Published by Oxford University Press (OUP) in Environmental Toxicology and Chemistry

Vol. 14 (12) , 2175-2179
https://doi.org/10.1002/etc.5620141222

Abstract

Newly fertilized lake trout (Salvelinus namaycush) eggs were exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), 3,3′,4,4′,5‐pentachlorobiphenyl (PCB 126), or their combination, and sac fry mortality was used to determine toxic potencies. The toxic equivalency factor (TEF) for PCB 126 was 0.0030. The dose‐response curve for the PCB 126/TCDD mixture based on TCDD toxic equivalents was not significantly different from that for TCDD alone, suggesting additivity between the two congeners in causing sac fry mortality.

Keywords

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