Sequence of PSE-2 beta-lactamase
Open Access
- 1 January 1988
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 32 (1) , 134-136
- https://doi.org/10.1128/aac.32.1.134
Abstract
The nucleotide sequence of PSE-2 beta-lactamase, an enzyme that readily hydrolyzes both carbenicillin and oxacillin, has been determined. The deduced sequence of 266 amino acids contained 93 residues identical to those of OXA-2 beta-lactamase and the Ser-Thr-Phe-Lys tetrad also found in the active site of TEM-1 beta-lactamase.This publication has 15 references indexed in Scilit:
- Rapid and Sensitive Protein Similarity SearchesScience, 1985
- Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesisGene, 1983
- Properties of PSE-2 beta-lactamase and genetic basis for its production in Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1983
- Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue.Proceedings of the National Academy of Sciences, 1982
- ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.Proceedings of the National Academy of Sciences, 1981
- Inactivation of the RTEM .beta.-lactamase from Escherichia coli. Interaction of penam sulfones with the enzymeBiochemistry, 1981
- The structure of β-lactamasesPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
- Plasmid-mediated β-lactamases of Gram-negative bacteria: properties and distributionJournal of Antimicrobial Chemotherapy, 1979
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977
- Gentamicin Resistance in Pseudomonas aeruginosa : R-Factor-Mediated ResistanceAntimicrobial Agents and Chemotherapy, 1974