ENHANCEMENT OF HUMAN MONOCYTE PHAGOCYTIC FUNCTION BY ALPHA-HS GLYCOPROTEIN

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (3) , 481-487
Abstract
Human .alpha.2HS glycoprotein was isolated from normal adult serum; its effect on monocyte phagocytic function in vitro was investigated. .alpha.2HS glycoprotein apparently enhances the ability of peripheral blood monocytes to take up radiolabeled latex particles compared to control cells. Enhanced uptake required the simultaneous presence of cells, substrate and .alpha.2HS glycoprotein. This uptake was dependent on the concentration of .alpha.2HS glycoprotein offering the possibility that reduced levels of this protein, as in malignant and inflammatory disease, may cause decreased phagocytic function.