A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin a and sa alkylation subunits
- 20 August 1996
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 6 (16) , 1955-1960
- https://doi.org/10.1016/0960-894x(96)00346-0
Abstract
No abstract availableThis publication has 31 references indexed in Scilit:
- A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivityBioorganic & Medicinal Chemistry Letters, 1996
- Enantioselective Total Synthesis of (+)-Duocarmycin A, epi-(+)-Duocarmycin A, and Their Unnatural EnantiomersJournal of the American Chemical Society, 1996
- Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995
- Design, Synthesis, and Evaluation of CC-1065 and Duocarmycin Analogs Incorporating the 2,3,10,10a-Tetrahydro-1H-cyclopropa[d]benzo[f]quinol-5-one (CBQ) Alkylation Subunit: Identification and Structural Origin of Subtle Stereoelectronic Features That Govern Reactivity and RegioselectivityJournal of the American Chemical Society, 1994
- Acid-Dependent Electrophilicity of Cyclopropylpyrroloindoles. Nature's Masking Strategy for a Potent DNA AlkylatorJournal of the American Chemical Society, 1994
- Chemical and Structural Comparison of N-BOC-CBQ and N-BOC-CBI: Identification and Structural Origin of an Unappreciated but Productive Stability of the CC-1065 and Duocarmycin SA Alkylation SubunitsJournal of the American Chemical Society, 1994
- (+)- and ent-(-)-Duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA Alkylation Properties.Alkylation Site Models That Accommodate the Offset AT-Rich Adenine N3 Alkylation Selectivity of the Enantiomeric AgentsJournal of the American Chemical Society, 1994
- Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophoreThe Journal of Organic Chemistry, 1990
- Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunitsJournal of the American Chemical Society, 1990
- Sequence selectivity of DNA covalent modificationChemical Research in Toxicology, 1988