Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-Promoted Mouse Skin Papilloma by Saponins
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 48 (1) , 77-80
- https://doi.org/10.1159/000226899
Abstract
Papillomas in mouse skin were initiated with 390 nmol of 7,12-dimethylbenz(a)anthracene and 1 week later, were promoted 2 times a week with 4.1 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA). Five saponin-related compounds used as potential anti-inflammatory agents were applied in the same position with 82 nmol. Saponin-related compounds effectively inhibited tumor formation in the sensitive mouse stock even when these compounds were given 1 h prior to TPA treatment. These results suggested that there was a general correlation between the anti-inflammatory and antitumor-promoting activities of saponins.Keywords
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