Rat Colon Carcinomas Associated with Aflatoxin and Marginal Vitamin A 2 3
- 1 February 1973
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 50 (2) , 439-448
- https://doi.org/10.1093/jnci/50.2.439
Abstract
Rats of the Charles River CD and the Fischer strains were exposed to aflatoxin B1 through a low concentration added to their diet or by gastric intubation. The diet was semisynthetic with refined sources of carbohydrate; some groups of animals were given deficient or marginal levels of vitamin A. Liver carcinomas were induced in a frequency expected from past experience with aflatoxin, without significant effect of the dietary concentration of vitamin A. On the other hand, 11 of 260 rats exposed to aflatoxin developed colon carcinomas, most of which were also associated with low dietary and hepatic concentrations of vitamin A.Keywords
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