Vitamin D Metabolism Is Altered in Asian Indians in the Southern United States: A Clinical Research Center Study

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Abstract
Asian Indians who immigrate to northern Europe have lower se- rum 25-hydroxyvitamin D (25(OH)D) than Caucasians, and they de- velop vitamin D deficiency, rickets, and osteomalacia. We investi- gated vitamin D metabolism, the effects of 25(OH)D3 on vitamin D metabolism and activity of 25(OH)D-24-hydroxylase, the rate-limit- ing enzyme for degradation of 25(OH)D, from cultured skin fibro- blasts of Asian Indians and compared them with cultured skin fibro- blasts of Caucasians in the southern United States. Normal subjects, ages 20 - 40 yr, were admitted to a metabolic ward for 2.5 days and given a daily diet containing 400 mg calcium and 900 mg phosphorus. Serum vitamin D, serum 25(OH)D, urinary calcium, and urinary phosphorus were significantly lower, whereas serum immunoreactive

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