Autoimmunity and Viruses—Fact or Fiction: Persistent LCM Viral Infection, Anti-LCM Viral Immune Response, and Tissue Injury
Open Access
- 1 September 1971
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 56 (3) , 299-302
- https://doi.org/10.1093/ajcp/56.3.299
Abstract
The concepts of autoimmunity immunologic tolerance, and slow virus infection(s) need to be re-examined. In the light of recent data from several laboratories, it has become clear that in those models of persistent viral infection carefully evaluated, the infected animal is not immunologically tolerant but is able to mount a definite, although lesser, immune response against the virus. The interaction of the host immune response with the virus is the cause, in part, of the associated tissue injury in chronic infection.Keywords
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