Role of Stress Response Sigma Factor SigG in Mycobacterium tuberculosis
Open Access
- 1 February 2008
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 190 (3) , 1128-1133
- https://doi.org/10.1128/jb.00511-07
Abstract
The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A ΔsigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.Keywords
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