Effects of Dextran Injections on Blood Viscosity in Dogs

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Abstract
Intravenous injections of dextrans cause physical changes in blood leading to increase in its viscosity. The degree of change is related directly to the molecular weight and dose of dextran. Injections of concentrated dextran solutions cause initial increase in plasma volume followed by prolonged decrease. Paralysis and electrocardiographic changes lasting 1–6 days were observed after injections of large molecular weight dextrans. Animals receiving no anesthesia or short-acting ones appear more tolerant of dextran than animals anesthetized by long-acting anesthetics. Submitted on April 3, 1956