A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists
- 30 October 2002
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 12 (23) , 3491-3495
- https://doi.org/10.1016/s0960-894x(02)00745-x
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Gonadotropin-releasing-hormone-receptor antagonistsThe Lancet, 2001
- 2-(3,5-Dimethylphenyl)tryptamine Derivatives that Bind to the GnRH ReceptorBioorganic & Medicinal Chemistry Letters, 2001
- Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindolesBioorganic & Medicinal Chemistry Letters, 2001
- SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonistsBioorganic & Medicinal Chemistry Letters, 2001
- Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituentsBioorganic & Medicinal Chemistry Letters, 2000
- Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamidesBioorganic & Medicinal Chemistry Letters, 2000
- Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonistBioorganic & Medicinal Chemistry Letters, 1999
- Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonistsBioorganic & Medicinal Chemistry Letters, 1999
- Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) ReceptorJournal of Medicinal Chemistry, 1998
- Synthetic analogs of luteinizing hormone releasing hormone (LH-RH) substituted in position 6 and 10Biochemical and Biophysical Research Communications, 1974