Muscle Abnormality in Ulcerative Colitis

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Abstract
Benign strictures, short or long, are uncommon in ulcerative colitis whether observed radiologically, sigmoidoscopically or in a colectomy specimen. There is a tendency to assume that they are due to fibrosis. But one of the more remarkable features of ulcerative colitis is its failure to provoke much fibroblastic proliferation and collagen formation, even when the inflammation has been severe, extensive and prolonged over many years. This contrasts with the excess collagen often found in Crohn's disease and always in ischemic stricture. There is a general, if slight, increase of submucosal collagen in some cases of very chronic ulcerative colitis, but . . .

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