Elimination and Metabolism of a Fat Emulsion Containing Medium Chain Triglycerides (Lipofundin MCT 10%)

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Abstract
Medium chain triglycerides (MCT) are supposed to be advantageous on account of rapid energy supply in parental nutrition. However, data on the elimination rate of MCT-containing emulsions during an intravenous fat-tolerance test (IVFTT) are scarce. We performed this test (0.1 g lipid/kg body weight) in 18 young healthy volunteers (nine females and nine males) using Lipofundin MCT 10% (50% MCT; egg phospholipids as emulsifier). Our results indicate that both elimination and metabolization of the emulsion are fast: a prompt decrease of light-scattering index and of triglyceride concentrations in serum, an immediate appearance of post-load fatty acids and of β-hydroxybutyrate were observed. This was in good agreement with the findings obtained during 6-hr infusions in the same probands.

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