Synthesis of 2‐chloroethyl (13C)‐methyl sulfide
- 1 November 1992
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 31 (11) , 849-851
- https://doi.org/10.1002/jlcr.2580311102
Abstract
Incorporation of a stable isotope‐labelled methylthio group into the mustard 2‐chloroethyl methyl sulfide 2 was complicated by concomitant reaction with iodide ion, a necessary byproduct from the precursor stable isotope‐labelled iodomethane. A two step procedure was therefore employed, initial displacement with mercaptoethanol 4 being followed by chlorination with thionyl chloride.Keywords
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