Infection of Mice with Tubercle Bacilli Grown in Tween-Albumin Liquid Medium

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Abstract
Mice of known genetic backgrounds were infected with young cultures of tubercle bacilli growing diffusely in the Tween albumin-liquid medium. Striking and reproducible differences were observed in the course and outcome of the infection resulting from injection of small amts. of bacilli by the intraperit. or intraven. routes. Of the 20 strains tested, mice derived from the Albino Swiss exhibited highest resistance, whereas pigmented strains were more susceptible. The infectivity of the culture can be enhanced by admixture with egg yolk prior to intraperit. injn.

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