Asymmetric Catalytic Reduction of Ketones with Hypervalent Trialkoxysilanes
- 1 October 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (10) , 1175-1178
- https://doi.org/10.1055/s-1997-982
Abstract
The catalytic asymmetric reduction of different ketones1 with transient hypervalent silicon hydrides is described. Trialkoxysilanes, upon activation by a small amount of a chiral nucleophile, underwent addition to the carbonyl group, forming the corresponding silyl protected alcohols, which were cleaved during the workup to give the enantiomerically enriched product alcohols. A brief screening of the reaction parameters and the results are summarized below.Keywords
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