Febrile Convulsions in Inbred Strains of Mice Susceptible and Resistant to Audiogenic Seizures

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Abstract
The incidence of febrile convulsions was determined in 6 inbred strains of mice at 4 ages. Febrile convulsions were elicited by placing the mice in a cylinder with the air temperature raised to 51 .+-. 2.degree. C; this elevated the mouse''s body and brain temperature to between 40-46.degree. C. The strains used were DBA/2Bg, DBA/1Bg, DBA/1Bg-ras, C57BL/10Bg, C57BL/6Bg and C57BL/6Bg-Gad-la; the ages were 21 .+-. 1, 29 .+-. 1, 59 .+-. 1 and 119 .+-. 1 days of age. DBA/2Bg, DBA/1Bg and C57BL/6Bg-Gad-1a are audiogenic seizure susceptible at 21 .+-. 1 and 29 .+-. 1 days of age but not at 59 .+-. 1 and 119 .+-. 1 days of age; C57BL/10Bg, C57BL/6Bg and DBA/1Bg-ras are audiogenic seizure resistant at all ages. Mice of both sexes, all strains and all ages had a febrile convulsion and died. In inbred mice there does not appear to be a genetic or developmental correlation between audiogenic seizures and febrile convulsions. This finding may be contrasted with that in other studies showing a correlation between susceptibility to audiogenic seizures and to electroshock convulsions or chemoconvulsions. There are subtle strain and age variants in susceptibility to febrile convulsions of these mice.

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