Anaphylactic Release of Histamine from Guinea Pig Skin in vitro
- 1 January 1972
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 42 (3) , 485-490
- https://doi.org/10.1159/000230628
Abstract
An in vitro system for the study of the mechanism of type 1 anaphylactic reactions is described using skin slices from actively sensitized guinea pigs. Anaphylactic histamine release was found to occur with low concentrations of antigen. Release of histamine was rapid and occurred over a narrow temperature range. This system appears to be a useful model for study of specificity of inhibitors of type 1 anaphylactic reaction.Keywords
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