Evaluation of urinary PrP Sc as a diagnostic test for sporadic, variant, and familial CJD
- 24 May 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 64 (10) , 1794-1796
- https://doi.org/10.1212/01.wnl.0000161842.68793.8a
Abstract
Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt–Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrPSc). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrPSc but appeared to be immunoglobulins.Keywords
This publication has 7 references indexed in Scilit:
- A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in UrineJournal of Biological Chemistry, 2004
- Creutzfeldt-Jakob disease and urinary gonadotrophinsHuman Reproduction, 2004
- Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins?Human Reproduction, 2002
- Bye-bye urinary gonadotrophins?Human Reproduction, 2002
- Bye-bye urinary gonadotrophins?: The use of urinary gonadotrophins should be discouragedHuman Reproduction, 2002
- A Protease-resistant Prion Protein Isoform Is Present in Urine of Animals and Humans Affected with Prion DiseasesJournal of Biological Chemistry, 2001
- PrionsProceedings of the National Academy of Sciences, 1998