Resistance to anti-peptide deformylase drugs
- 1 June 2001
- journal article
- Published by Informa Healthcare in Emerging Therapeutic Targets
- Vol. 5 (3) , 415-418
- https://doi.org/10.1517/14728222.5.3.415
Abstract
Recent work has assessed the potential of peptide deformylase (PDF) as a target for broad spectrum antibacterial agents. By using a number of approaches, including proteomics, researchers at Roche have shown that the molecules they had selected in vitro were able to target PDF in vivo. However, the authors, having observed resistance occurring at a rather high frequency and on the basis of the recent discovery of a deformylase homologue in humans, suggest that PDF ‘may not be an optimal target for broad spectrum antibacterial agents’. We link these data to results published by other laboratories and conclude that PDF deserves to still be considered a valuable target for new antibiotics.Keywords
This publication has 18 references indexed in Scilit:
- Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance DevelopmentAntimicrobial Agents and Chemotherapy, 2001
- Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase InhibitorAntimicrobial Agents and Chemotherapy, 2001
- Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanismsThe EMBO Journal, 2000
- Peptide Deformylase in Staphylococcus aureus : Resistance to Inhibition Is Mediated by Mutations in the Formyltransferase GeneAntimicrobial Agents and Chemotherapy, 2000
- Peptide deformylase as a target for new generation, broad spectrum antimicrobial agentsMolecular Microbiology, 2000
- Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial AgentsJournal of Medicinal Chemistry, 2000
- Synthesis and Antibacterial Activity of Peptide Deformylase InhibitorsBiochemistry, 2000
- Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase InhibitorBiochemistry, 2000
- Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferaseJournal of Bacteriology, 1994
- Methionine as translation start signal: A review of the enzymes of the pathway in Escherichia coliBiochimie, 1993