Effect of Heparin on Cytomegalovirus Replication

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Abstract
The presence of heparin in cell culture medium reduced the infectivity titers of cytomegaloviruses isolated from human, monkey, guinea pig and mouse. This inhibition increased as the heparin concentration was increased. When heparin was added to cultures after virus adsorption took place, the effect on virus infectivity was negligible. Other anticoagulants studied included Alsever''s solution, sodium citrate and EDTA, none of which showed any inhibitory effect on cytomegalovirus replication in cell culture.