Wilson's disease studied with FDG and positron emission tomography
- 1 November 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (11) , 1707
- https://doi.org/10.1212/wnl.37.11.1707
Abstract
Four patients with Wilson's disease and eight normal controls were studied with 2-deoxy-2-[18F]fluoro-d-glucose (FDG) and positron emission tomography (PET). The patients had diffusely reduced glucose metabolism in all brain regions evaluated compared with controls, with the exception of the thalamus. The ratio of the cerebral metabolic rate for glucose in the lenticular nuclei to hemispheres declined from 1.23 (± 0.14 SD) in controls to 1.03 (± 0.06) (p < 0.025) in Wilson's disease patients. Compared with Huntington's disease, the PET FDG results in Wilson's disease indicate relatively less focal involvement of the caudate nucleus, more severe focal changes in the lenticular nuclei, and more significant global changes in glucose metabolism.This publication has 9 references indexed in Scilit:
- Reduced Cerebral Glucose Metabolism in Asymptomatic Subjects at Risk for Huntington's DiseaseNew England Journal of Medicine, 1987
- Nuclear Magnetic Resonance (NMR) Imaging in Wilson DiseaseJournal of Computer Assisted Tomography, 1983
- Tomographic mapping of human cerebral metabolismNeurology, 1982
- Computed Tomography in Wilson's DiseaseArchives of Neurology, 1981
- Quantitation in Positron Emission Computed Tomography: 5. Physical–Anatomical EffectsJournal of Computer Assisted Tomography, 1981
- Computed tomography in Wilson diseaseNeurology, 1981
- Noninvasive determination of local cerebral metabolic rate of glucose in manAmerican Journal of Physiology-Endocrinology and Metabolism, 1980
- Computerized cranial tomography in Wilson diseaseNeurology, 1979
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977