The tumor spectrum in FHIT- deficient mice
- 21 August 2001
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 98 (18) , 10250-10255
- https://doi.org/10.1073/pnas.191345898
Abstract
Mice carrying one inactivated Fhit allele ( Fhit +/− mice) are highly susceptible to tumor induction by N- nitrosomethylbenzylamine, with 100% of Fhit +/− mice exhibiting tumors of the forestomach/squamocolumnar junction vs. 25% of Fhit +/+ controls. In the current study a single N- nitrosomethylbenzylamine dose was administered to Fhit +/+, +/−, and −/− mice to compare carcinogen susceptibility in +/- and −/− Fhit- deficient mice. At 29 weeks after treatment, 7.7% of wild-type mice had tumors. Of the Fhit −/− mice 89.5% exhibited tumors (average 3.3 tumors/mouse) of the forestomach and squamocolumnar junction; half of the −/− mice had medium (2 mm diameter) to large (>2 mm) tumors. Of the Fhit +/− mice 78% exhibited tumors (average 2.4 tumors/mouse) and 22% showed medium to large tumors. Untreated Fhit- deficient mice have been observed for up to 2 years for spontaneous tumors. Fhit +/− mice (average age 21 mo) exhibit an average of 0.94 tumors of different types; Fhit −/− mice (average age 16 mo) also showed an array of tumors (average 0.76 tumor/mouse). The similar spontaneous and induced tumor spectra observed in mice with one or both Fhit alleles inactivated suggests that Fhit may be a one-hit tumor suppressor gene in some tissues.Keywords
This publication has 22 references indexed in Scilit:
- FHIT gene therapy prevents tumor development in Fhit-deficient miceProceedings of the National Academy of Sciences, 2001
- Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.2001
- Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressorProceedings of the National Academy of Sciences, 2001
- Loss of Fhit expression is a predictor of poor outcome in tongue cancer.2001
- Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease.2000
- Muir–Torre-like syndrome in Fhit-deficient miceProceedings of the National Academy of Sciences, 2000
- Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival.2000
- THE ROLE OF THE FHIT/FRA3B LOCUS IN CANCERAnnual Review of Genetics, 1998
- Muir-Torre Phenotype Has a Frequency of DNA Mismatch-Repair-Gene Mutations Similar to That in Hereditary Nonpolyposis Colorectal Cancer Families Defined by the Amsterdam CriteriaAmerican Journal of Human Genetics, 1998
- The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract CancersCell, 1996