Metastases of Human Melanomas Transplanted in “Nude” Mice2

1 April 1973

journal article
research article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 50 (4) , 1051-1053
https://doi.org/10.1093/jnci/50.4.1051

Abstract

Three human melanomas grown in tissue culture were injected intradermally or subcutaneously into thymus-deficient “nude” mice. Invasive tumors were induced by 2 melanomas at the site of injection. All 3 metastasized to the cervical or inguinal lymph nodes and 1 to the lungs. Karyotypic analysis of the 3 metastatic tumors identified them as human.

Keywords

PATHOLOGY
MORPHOLOGY