Deregulation of protein synthesis as a mechanism of neoplastic transformation
- 1 March 1996
- Vol. 18 (3) , 243-250
- https://doi.org/10.1002/bies.950180312
Abstract
Early research on the cell cycle revealed correlations between protein accumulation and cell proliferation. In this review, I describe the data showing that abnormality of cell growth and tumor development are dependent upon oncogene‐induced increases in the levels and activity of factors that determine the rate of protein synthesis. It is proposed that the establishment of a vicious circle, namely oncoproteins → increase in translation → oncoproteins, is a major biological mechanism that fuels neoplastic growth. The constitutively high rates of protein synthesis and accumulation of proteins, including those necessary for DNA replication and mitosis, would drive cells to excessive proliferation.Keywords
This publication has 79 references indexed in Scilit:
- Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinaseScience, 1992
- The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.Genes & Development, 1992
- 2′,5′-oligoadenylate synthetase gene expression in revertants of ras-transformed NIH3T3 fibroblastsExperimental Cell Research, 1990
- Stimulation of lysosomal enzyme secretion by growth factorsExperimental Cell Research, 1990
- Transformed SV3T3 cells have a reduced lysosomal compartment and lower levels of enzyme activity than 3T3 cellsExperimental Cell Research, 1990
- BIOCHEMICAL INVESTIGATION OF HUMAN TUMOURS IN VIVO WITH PHOSPHORUS-31 MAGNETIC RESONANCE SPECTROSCOPYThe Lancet, 1986
- Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirusCell, 1985
- Growth arrest of AKR‐2B cells maintained in the presence of epidermal growth factor or 12‐O‐tetradecanolyhorbol‐13 acetate: Evidence for two separate G1 arrest pointsJournal of Cellular Physiology, 1980
- Transformed cells have lost control of ribosome number through their growth cycleJournal of Cellular Physiology, 1979
- On the Origin of Cancer CellsScience, 1956