Studies on Transmission of Maedi Virus to Lambs

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Abstract
Lambs born to 5 ewes in 3 successive years were studied for presence of maedi virus and its antibodies. In the middle of the first-year pregnancies the ewes and the only ram of the colony were inoculated with maedi virus. No antibodies or viraemia could be detected in the lambs at birth. After sucking colostrum, antibodies appeared in the lambs of the ewes which themselves were seropositive, and reached their peak in a few days. Maternal antibodies disappeared within 12 weeks in all the lambs. Neutralizing antibodies were demonstrated in the colostrum and their content declined rapidly after lambing. Virus was isolated from the milk of 2 ewes in the third year of the study In the first year the spread of maedi virus was demonstrated to only 1 of the lambs, but in the other 2 years maedi virus was detected in tissues of half of the lambs sacrificed at 3–12 weeks of age. It was concluded that lambs born to chronically infected ewes are readily infected, indicating excretion of virus by ewes. The study yielded no information on the specific routes of transmission, except for the finding of the virus in milk of 2 ewes in the third year of the study. No evidence was obtained of transplacental transmission of maedi.

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