THE ACUTE EFFECT OF SODIUM CELLULOSE PHOSPHATE ON INTESTINAL ABSORPTION AND URINARY EXCRETION OF CALCIUM IN MAN

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Abstract
Intestinal 47Ca absorption has been determined from blood and stool radioactivity after oral administration of the isotope in nine patients before and during cellulose phosphate treatment. Oral administration of 5 g cellulose phosphate concomitant with 47Ca in 100 mg “carrier” calcium as CaCl2 decreased 47Ca absorption by 80%. Cellulose phosphate, 5 g three times daily, decreased urinary excretion of non‐radioactive calcium by 47%. Urinary magnesium excretion decreased by 47%, whereas urinary phosphorus excretion increased by 67%. Calcium and magnesium excretion in urine decreases because cellulose phosphate binds divalent cations within the GI tract. The increased phosphorus excretion is probably due to partial hydrolysis of the substance in the gut.