Possible Role of Endotoxemia during Immunologic Imbalance

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Abstract
Transplantation of immunocytes (the graft-versus-host reaction, or GVHR) and, in many cases, immunosuppression (X-irradiation, cortisone overdosage, actinomycin D) or immunostimulation (Bacille Calmette Guerin, Corynebacterium parvum, etc.) decrease the host's resistance to endotoxins. In the present period of immunologic engineering, this situation may constitute a serious hazard. The data reported here demonstrate that (1) it is possible to obtain mycobacterial preparations that have lost their capacity to render mice susceptible to endotoxins, although they are still potent adjuvants or immunostimulants, and (2) the GVHR can be inhibited by in-vivo or in-vitro pretreatment with endotoxins.

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