Expression of Transforming Growth Factor (β)3 in Hypertrophic Juxtaglomerular Apparatus

Abstract
The mechanisms responsible for hypertrophy of the juxtaglomerular apparatus are not understood. We present histologic evidence to suggest that transforming growth factor β3 (TGF-β3), a multifunctional cytokine, may be regulated with renin and may have an important role in this hypertrophy.