THE BIOCHEMICAL EFFECTS OF INJECTIONS OF SEX HORMONES INTO HYPOPHYSECTOMIZED RATS

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Abstract
Daily sub-cut. injns. of 0.1 mg. of diethylstilbestrol and 0.2 mg. of testosterone propionate were given hypophysectomized d1 and 9 rats, respectively, for a 28-day period. There were no changes in the serum Ca, P, or alkaline phosphatase ac-tivity or the output of Ca and P in the feces. As in the intact and castrated rats, diethylstilbestrol produced a decrease in the acid phosphatase activity of the blood serum of the [male][male] while testosterone propionate in the [female][female] had no effect. The level of acid phosphatase activity of the blood serum was increased by hypophysectomy even more than by castration. The level of alkaline phosphatase activity of the bone was decreased by hypophysectomy.