Glucagon-Like Peptide-1(7-37) does not Stimulate either Hepatic Glycogenolysis or Ketogenesis.
- 1 January 1990
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 37 (2) , 293-297
- https://doi.org/10.1507/endocrj1954.37.293
Abstract
Recent Studies have demonstrated that glucagon-like peptide-1 (GPP)(7-37) has more potent insulinotropic activity than glucagon. We therefore examined the effect of GLP-1(7-37) on liver metabolism using rat liver perfusion system. Ten nM GLP-1(7-37) did not affect glucose, ketone body and cAMP outputs from the perfused liver. Whereas, the same dose of glucagon stimulated these outputs significantly. When 10nM GLP-1(7-37) perfused 5 min before the administration of 10 nM glucagon, the above stimulation effects of glucagon were not affected. These results indicate that truncated GLP-1 has no effect on hepatic glycogenolysis and ketogenesis dissociating from its potent insulinotropic activity.This publication has 1 reference indexed in Scilit:
- Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon.Journal of Biological Chemistry, 1984