Synthesis and Biological Applications of 2',3'-Dideoxynucleoside-5'-O-(α-thio)Triphosphates
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (5) , 849-853
- https://doi.org/10.1080/07328318908054228
Abstract
Fast and efficient syntheses of 2′,3′-dideoxynucleoside-5′-O-(α-thio)triphosphates (α-S-ddNTP's) starting from 2′-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3′-deoxythymidine is presented and compared to other known 2′,3′-dideoxynucleoside structures.Keywords
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