Vasodilator constituents of tissue extracts

Abstract
Histamine ([beta]-iminazolylethylamine) has been isolated in a state of chemical purity from an extract of fresh ox muscle under conditions which preclude its formation by autolysis or bacterial action. It is suggested that the depressor activity of muscle extracts prepared and tested under the given conditions is due entirely to histamine. No choline was detected. The distribution of depressor activity in extracts of various organs has been determined.

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