Therapy for Acute Cystitis in Adult Women
- 2 April 1982
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 247 (13) , 1839-1842
- https://doi.org/10.1001/jama.1982.03320380031023
Abstract
One hundred seventeen unselected women with symptoms of acute cystitis were randomized to groups for immediate therapy with one of the following four single-dose regimens: (1) 1 g of sulfisoxazole; (2) 2 g of sulfisoxazole; (3) a combination of trimethoprim, 160 mg, and sulfamethoxazole, 800 mg; and (4) a combination of trimethoprim, 320 mg, and sulfamethoxazole, 1,600 mg. Forty-one women were excluded, 13 did not return for follow-up, and 28 did not have significant bacteriuria in the pretherapy culture.Escherichia coliwas isolated in 81% of infections. Antibacterial activity was significantly greater in urine collected during the 24 hours after therapy in those who received trimethoprim-sulfamethoxazole. However, overall cure varied from 85% to 95%, without any great differences between the regimens. The rate of cure of 69% in the 13 patients with presumptive evidence of renal infection (antibody-coated bacteria present) was significantly lower than the rate of cure of 95% in women without evidence of renal infection. Single-dose therapy with these regimens was safe and effective in adult women with symptoms of acute cystitis, regardless of the localization of the site of infection. (JAMA1982;247:1839-1842)Keywords
This publication has 5 references indexed in Scilit:
- Urinary Infection Prophylaxis in WomenAnnals of Internal Medicine, 1981
- Urinary tract infections treated with single dose of short-acting sulphonamide.BMJ, 1979
- Efficacy of Single-Dose and Conventional Amoxicillin Therapy in Urinary-Tract Infection Localized by the Antibody-Coated Bacteria TechnicNew England Journal of Medicine, 1978
- A Controlled Study of Antimicrobial Prophylaxis of Recurrent Urinary Infection in WomenNew England Journal of Medicine, 1974
- Antibody-Coated Bacteria in the Urine and the Site of Urinary-Tract InfectionNew England Journal of Medicine, 1974