Action of analgesics on the kallikrein-kinin system
Open Access
- 1 January 1976
- journal article
- research article
- Published by Japanese Pharmacological Society in Folia Pharmacologica Japonica
- Vol. 72 (5) , 519-530
- https://doi.org/10.1254/fpj.72.519
Abstract
Aspirin，aminopyrine，およびmorphineの鎮痛作用をacetic acid writhing法，hot plate法，D'Amour and Smith法，およびRandall and Selitto法で検討し，kallikreinならびにkininaseのinhibitors併用時の鎮痛作用の増減，および脳内kininase活性の状態から，kininの落痛に対する役割と鎮痛薬の機序について考察した．本実験成績から，aspirinは末梢性に，aminopyrineおよびmorphineにも比較的強い末梢効果があることが示唆され，また末梢部位と脳内でのkininの作用に差があることが示唆された．This publication has 5 references indexed in Scilit:
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