PULMONARY TOXICITY STUDIES OF BLEOMYCIN AND TALISOMYCIN

  • 1 January 1981
    • journal article
    • research article
    • Vol. 65  (3-4) , 291-297
Abstract
The comparative pulmonary toxicity induced by [the antineoplastic drugs] bleomycin and talisomycin (former trivial name: tallysomycin A) was evaluated by measuring lung hydroxyproline content. Based on published subacute toxicity data, in which talisomycin was 4 times as toxic as bleomycin, the following doses of each drug were given s.c. to BDF1 male mice twice weekly for 4 wk: 2.5, 5 and 10 mg/kg of bleomycin and 0.625, 1.25, 2.5 and 3.75 mg/kg of talisomycin. Equivalent dose-related effects in body weight were produced by bleomycin and talisomycin at a respective dose ratio of 4:1. Similarly, equivalent dose-dependent increases in lung hydroxyproline content, an index of collagen, were produced by bleomycin and talisomycin. Neither drug caused deaths at the doses used.