Pentoxifylline does not Change Cerebral Blood Flow or Metabolism in the Dog

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Abstract
Pentoxifylline [a phosphodiesterase-inhibiting circulatory stimulator] 0.3-30 mg/kg was given i.v. to 6 dogs under NO2 anesthesia. Cerebral blood flow was measured with a sagittal sinus outflow technique, cerebral O2 consumption was calculated from the a-v [arterio-venous] difference, and metabolite levels were determined in biopsies of cerebral cortex. Pentoxifylline failed to influence cerebral blood flow or O2 consumption. There was no increase in cerebral levels of phosphocreatine, ATP or total adenine nucleotides; the only significant effect was higher glucose levels in dogs given pentoxifylline (4.49 .+-. 0.39 .mu.mol/g vs. 2.21 .+-. 0.18 .mu.mol/g). The latter was deleterious during cerebral ischemia. Pentoxifylline had no significant influence upon cerebral blood flow or metabolism in the dog likely to be of benefit during cerebral hypoxia or ischemia.