Furosemide-Induced Reduction in Ionized Calcium in Hypoparathyroid Patients

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Abstract
Six hypoparathyroid patients were treated with oral furosemide for 4 days. All 6 had a significant decrease in serum Ca2+ level from the control period (4.05 .+-. 0.31 mg/dl) to the furosemide period (3.46 .+-. 0.26 mg/dl, P < 0.005). In 5 patients, the decrease in serum Ca2+ concentration occurred in association with an increase in urinary Ca excretion. Although serum immunoreactive parathyroid hormone level increased in 5 patients, it was insufficient to return serum Ca2+ to control levels. Changes in serum P, Mg, or pH could not account for the observed decrease in serum Ca2+ concentration. It is necessary to monitor serum Ca2+ level in hypoparathyroid patients during furosemide therapy.

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