Influence of Interleukin 1α (IL-1α), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis
- 1 December 2008
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 15 (12) , 1888-1890
- https://doi.org/10.1128/cvi.00209-08
Abstract
The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1α (IL-1α) −889-C/T, IL-4 −1098-G/T and −590-C/T, and IL-6 −174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.Keywords
This publication has 19 references indexed in Scilit:
- In Vivo Interleukin-6 Protects Neutrophils from Apoptosis in OsteomyelitisInfection and Immunity, 2004
- IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiologyCytokine & Growth Factor Reviews, 2004
- Longitudinal data analysis in pedigree studiesGenetic Epidemiology, 2003
- IL‐1α (− 889) promoter polymorphism is a risk factor for osteomyelitisAmerican Journal of Medical Genetics Part A, 2003
- Interleukin-6 Deficiency Increases Inflammatory Bone DestructionInfection and Immunity, 2001
- Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank InteractionThe Journal of Experimental Medicine, 2000
- OsteomyelitisNew England Journal of Medicine, 1997
- Local and Systemic Inflammatory Mediator Release in Patients with Acute and Chronic Posttraumatic OsteomyelitisThe Journal of Trauma: Injury, Infection, and Critical Care, 1996
- Role of cytokines in bone resorptionBone, 1995
- Interleukin‐4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritisArthritis & Rheumatism, 1994