Danazol for the Treatment of Idiopathic Thrombocytopenic Purpura

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Abstract
Fourteen patients with idiopathic thrombocytopenic purpura (ITP) refractory to steroids and/or splenectomy were treated with danazol (200 mg 3 times a day) for 2 months. The following responses were achieved; excellent (platelet count > 100 .times. 109/l) in 5 patients; good (> 50 .times. 109/l, but < 100 .times. 109/l) in 2 patients, and poor in (no increase of platelet count) 7 patients. In three cases remission lasted more than 7 months. Danazol was well tolerated and in most patients better suited than steroids for long-term intake.