Studies on the Metabolism of Sulfadimethoxine. II. Determinations of Metabolites in Human and Rabbit Urine after Oral Administration of Sulfadimethoxine.
- 1 January 1967
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 15 (9) , 1272-1276
- https://doi.org/10.1248/cpb.15.1272
Abstract
The concentration and the amounts of sulfadimethoxine metabolites in both human and rabbit urine were determined separately using paper chromatography for 168 hr. after administration. In human urine the main metabolite was sulfadimethoxine-N1-glucuronide, and more than 70% of the whole metabolites was excreted in this form. In the case of rabbit, the main metabolite was N4-acetyl sulfadimethoxine.This publication has 1 reference indexed in Scilit:
- Metabolism of N1-(2-methyl-6-methoxy-4-pyrimidinyl) sulfanilamide (sulfamethomidine) in the rat, the rabbit, and the dogToxicology and Applied Pharmacology, 1962