Transport of Epinephrine and Norepinephrine in Human Plasma.

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Abstract
Plasma pools collected in anticoagulant acid citrate dextrose (ACD) solution or through cationic exchange resins were fractionated with Cohn''s cold ethanol Method 6 of plasma fractiona-tion, and the separated fractions were analyzed for epinephrine (E) and norepinephrine (NE), chemically and biologically. Although the E is almost completely bound to plasma proteins, an appreciable amount of NE seems to be unbound. The plasma protein responsible for the binding and the transport of both E and NE is in the albumin. A part of E possibly binds also with Fraction IV-4. The increase of E and NE activity following acid hydrolysis suggests the presence of a conjugated form, binding to albumin, which is released by acid hydrolysis.

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