In Vitro Activities of DU-1102, a New Trioxaquine Derivative, againstPlasmodium falciparumIsolates
Open Access
- 1 June 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (6) , 1886-1888
- https://doi.org/10.1128/aac.45.6.1886-1888.2001
Abstract
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) ofPlasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.Keywords
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