The endocrine factors concerned in the control of the ovarian cycle

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Abstract
II. Ovulation without oviposition can be induced by injection of saline suspensions of anterior lobe pituitary tissue in the common frog Rana temporaria. Oviposition occurs in only a few injected animals and is never complete as in the normal animal. Ovulation induced by single injections cannot be obtained during the whole yr.[long dash]III. Alkaline extracts of anterior lobe pituitary injected in equivalent dosage throughout the whole range of effective conc. are as effective as acid extracts in producing ovulation in Xenopus laevis. By keeping toads at a high temp. (23-31[degree]) the time elapsing between injection and ovulation can be reduced from an av. of 18 to 9 hrs., thereby increasing the value of the animal for test purposes. Temp. variation was not found to have any perceptible effect on the sensitivity of the response of ovulation to injection of extract.