A Three-Dimensional Consideration of Variant Human Fibrinogens
- 1 January 1998
- journal article
- review article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 80 (07) , 1-9
- https://doi.org/10.1055/s-0037-1615130
Abstract
Recently reported X-ray structures for large core fragments derived from human fibrinogen and fibrin make it possible to correlate structural and functional anomalies of known genetic variants. Here we examine a variety of amino acid replacements previously reported for hereditary dysfibrinogenemias, most of which are associated with impaired fibrin polymerization. For many of these we have modeled in the mutant amino acid and considered the structural consequences. We have also examined the cases of a small deletion and a large insertion, as well as the impact of substitutions in the GPRPam ligand that was co-crystallized with fragment double-D.Keywords
This publication has 30 references indexed in Scilit:
- Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrinNature, 1997
- Crystal structure of a 30 kDa C-terminal fragment from the γ chain of human fibrinogenStructure, 1997
- Inherited Dysfibrinogenemia: Emerging Abnormal Structure Associations With Pathologic and Nonpathologic DysfunctionsSeminars in Thrombosis and Hemostasis, 1993
- Congenital Fibrinogen AbnormalitiesAnnals of the New York Academy of Sciences, 1983
- Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differencesBiochemistry, 1980
- Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomersProceedings of the National Academy of Sciences, 1978
- γ-γ Cross-linking sites in human and bovine fibrinBiochemistry, 1971
- Subunit Structure of Human Fibrinogen, Soluble Fibrin, and Cross-Linked Insoluble FibrinProceedings of the National Academy of Sciences, 1970
- Molecular Pathology of Human HaemoglobinNature, 1968
- On the Significance of the Release of Two Different Peptides from Fibrinogen During Clotting.Acta Chemica Scandinavica, 1958