Variations in Solid-Phase Extraction of Basic Drugs Using Bonded Silica. III. Phase-To-Phase Variations
- 1 June 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 14 (9) , 1671-1682
- https://doi.org/10.1080/01483919108049644
Abstract
Phase-to-phase variations of solid-phase extraction of basic drugs were studied using elution profiles obtained after elution of three model drugs from C18-, C8- and CN-silica. Variations were observed in the extraction of model drugs (in total recovery as well as in the course of elution profiles) and of endogenous compounds from serum. Various types of interactions depending on hydro-phobic properties of the drugs and of the silica-modifiers were found to affect the process., Hydrophobia interactions facilitated not only adsorption but also elution of hydrophobic drugs from hydrophobic sorbents.Keywords
This publication has 11 references indexed in Scilit:
- Polar Interactions in Solid-Phase Extraction of Basic Drugs by Octadecylsilanized SilicaJournal of Chromatographic Science, 1990
- Selective solid-phase extraction of basic drugs by C8-silica. Discussion of possible interactionsJournal of Pharmaceutical and Biomedical Analysis, 1990
- Drug Lipophilicity in QSAR Practice: I. A Comparison of Experimental with Calculative ApproachesQuantitative Structure-Activity Relationships, 1990
- Sample preparation for biomedical analysisJournal of Chromatography B: Biomedical Sciences and Applications, 1989
- Fluorimetric assay of stobadine in serum of dogsJournal of Pharmaceutical and Biomedical Analysis, 1989
- Biological Sample Preparation and Data Reduction Concepts in Pharmaceutical AnalysisJournal of Chromatographic Science, 1988
- Isolation of basic drugs from plasma using solid-phase extraction with a cyanopropyl-bonded phaseJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Gas chromatographic determination of stobadine, N-desmethylstobadine and stobadine N-oxide in rat liver microsomal incubationsJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- The disposition of the local anaesthetic, pentacaine, in rats and miceBiopharmaceutics & Drug Disposition, 1986
- Effects of different buffer species on partition coefficients of drugs used in quantitative structure–activity relationshipsJournal of Pharmaceutical Sciences, 1980