Studies on Ethionine. VII. Fatty Acid Synthesis in Livers of Ethionine-Treated Rats.

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Abstract
Summary The effect of administration of ethionine upon fatty acid synthesis in a system from the livers of female and male rats has been investigated. Three hours after administration of ethionine, fatty acid synthesis in the livers of both sexes was reduced to about 50% of the control. At 5 hours, male rats recovered from the initial inhibition to 77% of the control, whereas the synthesis in females was further reduced to 24% It was found that the ethionine effect was not merely due to a deficiency in the supply, or in availability of ATP, NADPH, or CoA. Nor was the impairment due to an accumulation of ethionine itself or S-adenosylethio-nine. The possibility is considered that the inhibition of fatty acid synthesis at 5 hours in the liver of female rats may result from the inhibition of the synthesis of acetyl-CoA carboxylase, which is found in the supernatant fraction, in addition to a partial impairment of microsomal function. The cause of the inhibition observed at 3 hours for both sexes remains to be determined.

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